Look at the assumptions you baked into your original plan. Did the city follow through on opening that new park across from your location? Were insurance rates what you expected? How many hours of accounting or web design help did you really need? Are your online inquiries out_stripping your face_to_face sales? Or vice versa? Sometimes no matter how much you research, plan, or test, things don't go as expected in a business. This isn't necessarily a herald of failure or a sign that you're not cut out for entrepreneurship. Life and the marketplace are both unpredictable, and plans need to be fluid and responsive. The "One Pressing Issue Plan" is simply a reflection of a normal evaluation process.
Then there are the moments when something seems to be going wrong, when one or more areas of the business just don't seem to be working. Cash flow is anemic or the marketing message is flat. Perhaps customers have shown a marked interest in only one particular product or service, ignoring all your other offerings. This means it's time to revisit your business plan, more precisely it's time to revisit the questioning process that helped you craft your plan.